Type 1 diabetes and islet transplantation: Identifying the cell death signalling pathways by which non-immune factors such as islet amyloid formation mediate beta-cell death in human islets during pre-transplant culture and following transplantation. Through these studies we hope to find new approaches to enhance survival and function of islet grafts in type 1 diabetic recipients.
Type 2 diabetes and beta-cell apoptosis: Identifying the molecular mechanisms by which islet amyloid formation mediates beta-cell death in type 2 diabetes and finding new ways to prevent amyloid toxicity.
Role of islet alpha cells in diabetes: Investigating the underlying molecular mechanisms that contribute to the better survival of islet alpha-cells in conditions associated with beta-cell death such as type 2 diabetes, islet culture, and transplantation.
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2] Park YJ, Lee S, Kieffer TJ, Warnock GL, Safikhan N, Speck M, Hao Z, Woo M, Marzban L: Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide. Diabetologia 55(4): 1035-1047, 2012.
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