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Antibody Engineering Facility

Antibodies are indispensable tools for research, diagnosis, and therapy. Single-chain antibodies (scFvs) can be used for all the same applications as conventional monoclonal and polyclonal antibodies, but are much more versatile, reliable, and robust.  The Infection and Immunity Research Centre (IIRC) Antibody Engineering Facility at the Jack Bell Research Centre provides antibody engineering services with scFvs, which can be selected and produced against proteins, peptides, and haptens, such as cell wall components. These antibodies are generated by fusing the variable light and heavy chains of immunoglobulins and are selected from a library using phage display technology. Selected scFvs are produced as recombinant proteins, and can have various properties, such as affinity, valency, specificity, stability, serum half-life, and fluorescence, modified and improved.

Products and Services:

The IIRC Antibody Engineering Facility provides a range of services; including screening and production of recombinant scFvs, production of antigens, as well as modification of the selected antibodies. Our experienced personnel can also assist in the design, use and application of scFvs.

Antibody Production

–      minimum production time of 1 month
–      250-500 micrograms produced in each batch

Cloning and Protein Production of Antigen

–      minimum production time of 1 month

Antibody Subcloning

–      production time of approximately 3 weeks.

Antibody facility photos 003  Antibody facility photos 004

For more information, contact:

Dr. Horacio Bach – Faculty Manager
604-727-9719
horacio.bach@gmail.com

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