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Theodore Steiner, MD

Associate Professor
Division of Infectious Diseases

Associate Member
Department of Microbiology and Immunology, UBC

phone: 604-875-4111 x68492
fax: 604-244-9910

tsteiner(at)interchange.ubc.ca

www.id.med.ubc.ca/Faculty/Faculty_Steiner.htm

The Role of Flagellin in Anti-Bacterial Inflammatory Responses

We study the inflammatory response to the flagellin from enteroaggregative E. coli (EAEC), an emerging diarrheal pathogen. Bacterial flagellins are recognized by Toll-like receptor 5 (TLR5), leading to NF-kB activation, chemokine release, T-cell activation, and other inflammatory phenotypes. Our work is currently focused on several key projects:

1. Studies of molecular inflammatory signalling in response to bacterial flagellin acting through Toll-like receptor 5 (TLR5).
2. Identifying the role of flagellin/TLR5 interaction in the abnormal inflammatory responses that characterize Crohn’s disease
3. Studies of flagellin-reactive effector and regulatory populations of T cells in the human gut in inflammatory bowel disease
4. Pathogenic mechanisms of infectious diarrhea due to enteroaggregative E. coli

Clinical Expertise

General consultative infectious diseases, with a particular interest in infectious diarrhea and tropical medicine


Education

MD - Duke University

BSc - Biochemical Sciences - Harvard


Selected Publications

Ivison SM, Graham NR, Bernales CQ, Kifayet A, Ng N, Shobab LA, Steiner TS. Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin. J Immunol. 2007 May 1;178(9):5735-43.

Ivison SM, Khan MA, Graham NR, Bernales CQ, Kaleem A, Tirling CO, Cherkasov A, Steiner TS. A phosphorylation site in the Toll-like receptor 5 TIR domain is required for inflammatory signalling in response to flagellin. Biochem Biophys Res Commun. 2007 Jan 26;352(4):936-41.

Steiner TS. How flagellin and toll-like receptor 5 contribute to enteric infection. Infect Immun. 2007 Feb;75(2):545-52.

Steiner TS, Samie A, Guerrant RL. Infectious diarrhea: new pathogens and new challenges in developed and developing areas. Clin Infect Dis. 2006 Aug 15;43(4):408-10.

Khan MA, Kang J, Steiner TS. Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activation. Immunology. 2004 Aug;112(4):651-60.

Donnelly MA, Steiner TS. Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5. J Biol Chem. 2002 Oct 25;277(43):40456-61.

Guerrant RL, Van Gilder T, Steiner TS, Thielman NM, Slutsker L, Tauxe RV, Hennessy T, Griffin PM, DuPont H, Sack RB, Tarr P, Neill M, Nachamkin I, Reller LB, Osterholm MT, Bennish ML, Pickering LK; Infectious Diseases Society of America. Practice guidelines for the management of infectious diarrhea. Clin Infect Dis. 2001 Feb 1;32(3):331-51.

Steiner TS, Nataro JP, Poteet-Smith CE, Smith JA, Guerrant RL. Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells. J Clin Invest. 2000 Jun;105(12):1769-77.