Alice Mui, PhD
Assistant Professor
Department of Surgery, UBC
Co-Director
Centre for Surgical Research
phone: 604-875-5555 x62242
fax: 604-875-4497
alice.mui(at)ubc.ca
Inflammatory Signalling Pathways
Dr. Mui's laboratory studies the mechanism by which negative regulators like IL10 inhibit target cells in order to intervene therapeutically during deregulated immune responses. Her group has identified an agonist of the inositol phosphatase SHIP, which mimics the anti-inflammatory action of IL10. Her laboratory confirmed that the agonist inhibits inflammation in animal models of septicemia and colitis - both diseases resulting from over-enthusiastic activation of the immune system. The agonist has now been licensed to a spin-off company for clinical development for the treatment of human inflammatory disease. The Mui lab is now characterizing small molecule SHIP inhibitors which might be used to reverse pathogen-induced immunosuppression. Work is also continuing towards characterizing other signalling pathways utilized by IL10 and other negative immune cell regulators.
Education
PhD - Pathology - University of British Columbia
BSc - Biochemistry - University of British Columbia