Levings Lab Members


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Dr. Raewyn Broady
Clinical Scientist

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Rosa Garcia
Research Technician

phone: 604-875-4111 x61052

rogarcia(at)interchange.ubc.ca


Besides making sure things in the Lab run smoothly, Rosa's research interest is on signaling pathways in T regulatory cells, mostly the PI3K/AKT pathway. The Lab has recently shown a defect in this pathway after TCR stimulation when we compare T reg and T effectors cells.  Rosa is currently investigating the impact of this difference on the T reg phenotype.
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Jana Gillies
Research Technician

janak(at)interchange.ubc.ca

IPEX is a fatal autoimmune disease caused by a defect in the development of regulatory T cells. The disease results from mutations in FoxP3, a transcription factor which is necessary for the development of regulatory T cells. My project is aimed at understanding how the FoxP3 mutations found in IPEX lead to this regulatory T cell defect.
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Dr. Gijs Hardenberg
Post-doctoral Fellow

gijs(at)interchange.ubc.ca

Research Project: The role of regulatory T cells and flagellin in inflammatory bowel disease
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Megan Himmel
PhD Candidate

Mhimmel(at)interchange.ubc.ca

I am working on a CIHR team grant focused on elucidating the cause of inflammatory bowel disease (IBD). This condition is believed to be mediated by autoreactive T cells and inappropriately activated innate immune cells. My work focuses on how T regulatory cells control IBD, as well as how the TLR5 ligand flagellin contributes to the pathogenesis of this disease.
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Alicia McMurchy
PhD Candidate
 
FOXP3 is a protein that is critical for the function of T regulatory (Treg) cells. Patients who lack functional FOXP3 develop a severe autoimmune disease called IPEX which often results in fatality early in life. Part of my research involves defining how different mutations of FOXP3 affect the molecular and cellular function of Treg cells and how functional deficits correlate with clinical symptoms of IPEX.
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Dr. Scott Patterson
Post-doctoral Fellow

I am currently investigating the mechanisms in which the PI3K pathway co-regulates the development of Tregs and TH17 cells.
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Adele Wang

PhD Candidate

In many patients with cancer, a type of immunosuppressive cell, termed T regulatory (Treg) cells can inhibit the immune response to cancer cells. My research aims to identify a population of antigen-presenting cells that can stimulate anti-cancer T cell responses and simultaneously limit the function of suppressive Treg cells. This work will enhance the efficiency of new cell-based anti-tumour vaccines for women with breast cancer.
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Jessie Yu
Research Technician

My research examines the roles of T regulatory and Th17 cells in graft versus host disease (GvHD). Blood samples have been collected from more than 50 transplant patients and we are using these samples to study the cytokine profiles of early stage GvHD.


Former Lab Members

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Sarah Allan, PhD 2007


Currently Executive
Editor for the Journal
of Cell Science.
Sarah Allan, PhD 2006


Currently Postdoctoral
fellow
at Genentech
Andrew Hall
Postdoctoral Fellow

Currently a Research Associate at the University of Aberdeen.

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Andrew Hurlbert
summer student 2007

Currently finishing a BSc
Christine Kang
Coop student, 2007

Currently finishing a BSc
Natasha Locke
Postdoctoral fellow

 
Currently back home in Melbourne


Lab Hike - August 2008

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